methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate

Base Information

Chemical Name:methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate
CAS No.:1233250-11-7
Molecular Formula:C₃₀H₂₇ClN₂O₄
Molecular Weight:515.008
Hs Code.:

Synonyms:methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate

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Chemical Property of methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate

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Technology Process of methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate

There total 3 articles about methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1233250-10-6
methyl 2-[1-(4-carboxyphenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate

: 156-41-2
4-chlorophenylethylamine

: 1233250-11-7
methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 1233250-09-3
tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate

: 1233250-11-7
methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / chloroform / 20 °C

2: water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In chloroform;
DOI:10.1016/j.bmcl.2012.03.009