tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate

Base Information

Chemical Name:tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate
CAS No.:1233250-09-3
Molecular Formula:C₂₆H₂₇NO₅
Molecular Weight:433.504
Hs Code.:

Synonyms:tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate

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Chemical Property of tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate

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Technology Process of tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate

There total 1 articles about tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1233249-59-6
tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

: 74-88-4
methyl iodide

: 1233250-09-3
tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate

Guidance literature:: tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 1233250-09-3
tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate

: 1233250-11-7
methyl 2-[1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yl]-2-methylpropinate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / chloroform / 20 °C

2: water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In chloroform;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233250-09-3
tert-butyl 4-[4-(2-methoxy-1,1-dimethyl-2-oxo-ethyl)isoquinoline-1-carbonyl]benzoate

: 1233249-28-9
2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / chloroform / 20 °C

2: water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 20 °C

3: water; lithium hydroxide / 1,4-dioxane / 100 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; chloroform;
DOI:10.1016/j.bmcl.2012.03.009