Technology Process of (3aS,4R,6R,7S,7aR)-6-Allyl-7-benzyloxy-4-((S)-1-benzyloxy-but-3-enyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran
There total 9 articles about (3aS,4R,6R,7S,7aR)-6-Allyl-7-benzyloxy-4-((S)-1-benzyloxy-but-3-enyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetra-(n-butyl)ammonium iodide; sodium hydride;
In
tetrahydrofuran;
at 25 ℃;
for 22h;
DOI:10.1055/s-2002-33511
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 89 percent / MeONa / methanol / 48 h / 0 °C
2: imidazole / dimethylformamide / 0.5 h / 24 °C
3: CSA / 1.5 h / 24 °C
4: 99 percent / NaI; Bu4NI / tetrahydrofuran / 30 h / 24 °C
5: 100 percent / TBAF / tetrahydrofuran / 2 h / 23 °C
6: (COCl)2; DMSO; Et3N / CH2Cl2 / 0.42 h / -78 - 0 °C
7: LiClO4 / diethyl ether / 23 h / 23 °C
8: 100 percent / NaH; Bu4NI / tetrahydrofuran / 22 h / 25 °C
With
1H-imidazole; oxalyl dichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; sodium methylate; lithium perchlorate; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine; sodium iodide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
6: Swern oxidation;
DOI:10.1055/s-2002-33511
- Guidance literature:
-
Multi-step reaction with 7 steps
1: imidazole / dimethylformamide / 0.5 h / 24 °C
2: CSA / 1.5 h / 24 °C
3: 99 percent / NaI; Bu4NI / tetrahydrofuran / 30 h / 24 °C
4: 100 percent / TBAF / tetrahydrofuran / 2 h / 23 °C
5: (COCl)2; DMSO; Et3N / CH2Cl2 / 0.42 h / -78 - 0 °C
6: LiClO4 / diethyl ether / 23 h / 23 °C
7: 100 percent / NaH; Bu4NI / tetrahydrofuran / 22 h / 25 °C
With
1H-imidazole; oxalyl dichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; lithium perchlorate; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine; sodium iodide;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
5: Swern oxidation;
DOI:10.1055/s-2002-33511
