3-(4-bromophenyl)-2-(phenylthio)-2H-pyrido[3,2-b][1,4]oxazine

Base Information

• Chemical Name: 3-(4-bromophenyl)-2-(phenylthio)-2H-pyrido[3,2-b][1,4]oxazine
• CAS No.: 1255647-86-9
• Molecular Formula: C₁₉H₁₃BrN₂OS
• Molecular Weight: 397.295
• Mol file: 1255647-86-9.mol

Synonyms:3-(4-bromophenyl)-2-(phenylthio)-2H-pyrido[3,2-b][1,4]oxazine

Chemical Property of 3-(4-bromophenyl)-2-(phenylthio)-2H-pyrido[3,2-b][1,4]oxazine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-(4-bromophenyl)-2-(phenylthio)-2H-pyrido[3,2-b][1,4]oxazine

There total 1 articles about 3-(4-bromophenyl)-2-(phenylthio)-2H-pyrido[3,2-b][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-amino-3-hydroxypyridine (16867-03-1) + 2-bromo-1-(4-bromo-phenyl)-2-phenylsulfanyl-ethanone (102880-95-5) → 3-(4-bromophenyl)-2-(phenylthio)-2H-pyrido[3,2-b][1,4]oxazine (1255647-86-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl acetamide; at 20 ℃;

DOI:10.1055/s-0030-1260085

Reference yield: 73.0%

3-(4-bromophenyl)-2-(phenylthio)-2H-pyrido[3,2-b][1,4]oxazine (1255647-86-9) → 3-(4-bromophenyl)-2-fluoro-2H-pyrido[3,2-b][1,4]-oxazine (1255647-94-9)

Guidance literature:

With N-Bromosuccinimide; triethylamine tris(hydrogen fluoride); In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0030-1258517

upstream raw materials:

2-amino-3-hydroxypyridine

2-bromo-1-(4-bromo-phenyl)-2-phenylsulfanyl-ethanone

Downstream raw materials:

3-(4-bromophenyl)-2-fluoro-2H-pyrido[3,2-b][1,4]-oxazine