3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

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Chemical Name:3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole
CAS No.:863561-58-4
Molecular Formula:C₃₈H₅₂N₄O
Molecular Weight:580.857
Hs Code.:

Synonyms:3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

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Chemical Property of 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

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Technology Process of 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

There total 15 articles about 3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 863561-73-3
C₃₁H₄₆N₄O

: 100-52-7
benzaldehyde

: 863561-58-4
3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

Guidance literature:: C₃₁H₄₆N₄O; benzaldehyde; acetic acid; In methanol;

With sodium cyanoborohydride; In methanol; at 0 - 20 ℃; for 2h;

Reference yield:

: 666852-63-7
ethyl 2-methyl-2-(2-thienyl)propanoate

: 863561-58-4
3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 11 steps

1.1: nitronium tetrafluoborate / 1,2-dimethoxyethane / 4 h / -55 - -10 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 5 h / 1140.08 Torr

3.1: tetrahydrofuran / 16 h / Heating / reflux

4.1: sodium hydroxide; water / ethanol / 1.5 h / Heating / reflux

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h

5.2: 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h

6.2: 5 - 20 °C

7.1: hydrogenchloride / 1,4-dioxane; iso-butanol / 1 h / 90 °C

8.1: hydrazine / ethanol / 16 h / 20 °C

9.1: sodium cyanoborohydride / acetic acid / methanol

10.1: hydrogen / nickel / methanol; ethanol / 2 h / 20 °C / 1292.09 Torr

11.1: acetic acid / methanol

11.2: 2 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium hydroxide; nitronium tetrafluoborate; water; hydrogen; sodium hydride; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; palladium 10% on activated carbon; nickel; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; iso-butanol;

Reference yield:

: 1000819-06-6
C₁₀H₁₅NO₂S

: 863561-58-4
3-[3,3-dimethyl-4-oxo-4-(7-azabicyclo[2.2.1]heptan-7-yl)butyl]-4-[(1S)-1-methyl-2-{1-benzyl-pyrrolidin-3-ylamino}ethyl]-5-(3,5-dimethylphenyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran / 16 h / Heating / reflux

2.1: sodium hydroxide; water / ethanol / 1.5 h / Heating / reflux

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h

3.2: 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h

4.2: 5 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane; iso-butanol / 1 h / 90 °C

6.1: hydrazine / ethanol / 16 h / 20 °C

7.1: sodium cyanoborohydride / acetic acid / methanol

8.1: hydrogen / nickel / methanol; ethanol / 2 h / 20 °C / 1292.09 Torr

9.1: acetic acid / methanol

9.2: 2 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium hydroxide; water; hydrogen; sodium hydride; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; nickel; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; iso-butanol;