Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate

Base Information

Chemical Name:Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate
CAS No.:86748-67-6
Molecular Formula:C₂₂H₃₇NO₂Si₃
Molecular Weight:431.798
Hs Code.:

Synonyms:Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate

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Chemical Property of Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate

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Technology Process of Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate

There total 3 articles about Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 100-39-0
benzyl bromide

: 86748-66-5
1-{1-[1-Methoxy-1-trimethylsilanyloxy-meth-(E)-ylidene]-4-trimethylsilanyl-but-3-ynyl}-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine

: 86748-67-6
Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate

Guidance literature:: With zinc dibromide; In dichloromethane; at 25 ℃; for 24h;
DOI:10.1021/jo00167a032

Reference yield:

: 86748-64-3
Methyl 2-(2,2,5,5-tetramethyl-2,5-disilyl-1-azacyclopentyl)glycinate

: 86748-67-6
Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi, diisopropylamine / 1.) hexane, THF, -10 deg C, 15 min, 2.) THF, HMPA, -78 deg C, 1h; 25 deg C, 1h

2: 1.) (Me₃Si)2NLi (n-BuLi, hexamethyldisilazane)

3: 66 percent / anhydrous zinc bromide / CH₂Cl₂ / 24 h / 25 °C

With n-butyllithium; diisopropylamine; zinc dibromide; lithium hexamethyldisilazane; In dichloromethane;
DOI:10.1021/jo00167a032

Reference yield:

: 86748-65-4
Methyl 2-(2,2,5,5-Tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate

: 86748-67-6
Methyl 2-Benzyl-2-(2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentyl)-5-(trimethylsilyl)-4-pentynoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (Me₃Si)2NLi (n-BuLi, hexamethyldisilazane)

2: 66 percent / anhydrous zinc bromide / CH₂Cl₂ / 24 h / 25 °C

With zinc dibromide; lithium hexamethyldisilazane; In dichloromethane;
DOI:10.1021/jo00167a032