3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.1^3,7]decaneacetonitrile

Base Information

• Chemical Name: 3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.1^3,7]decaneacetonitrile
• CAS No.: 1449650-88-7
• Molecular Formula: C₂₃H₃₀N₂
• Molecular Weight: 334.505
• Mol file: 1449650-88-7.mol

Synonyms:3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.1^3,7]decaneacetonitrile

Chemical Property of 3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.1^3,7]decaneacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.1^3,7]decaneacetonitrile

There total 3 articles about 3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.1^3,7]decaneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

trimethylsilyl cyanide (7677-24-9) + 3-cyclopentyl-1-tricyclo[3.3.1.13,7]decanecarboxaldehyde (1449650-83-2) + aniline (62-53-3) → 3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.13,7]decaneacetonitrile (1449650-88-7)

Guidance literature:

In acetonitrile; at 20 ℃; for 45h; Inert atmosphere;

DOI:10.1039/c3md00081h

Reference yield:

3-cyclopentyl-1-tricyclo<3.3.1.1.3,7>decanecarboxylic acid (160013-51-4) → 3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.13,7]decaneacetonitrile (1449650-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

1.2: 0 °C

2.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.1: acetonitrile / 45 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetonitrile; 3.1: |Strecker Aminoacid Synthesis;

DOI:10.1039/c3md00081h

Reference yield:

3-cyclopentyl-1-tricyclo[3.3.1.13,7]decanemethanol → 3-cyclopentyl-α-phenylamino-1-tricyclo[3.3.1.13,7]decaneacetonitrile (1449650-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2: acetonitrile / 45 h / 20 °C / Inert atmosphere

With pyridinium chlorochromate; In dichloromethane; acetonitrile; 2: |Strecker Aminoacid Synthesis;

DOI:10.1039/c3md00081h

upstream raw materials:

trimethylsilyl cyanide

3-cyclopentyl-1-tricyclo[3.3.1.1^3,7]decanecarboxaldehyde

aniline

3-cyclopentyl-1-tricyclo<3.3.1.1.^3,7>decanecarboxylic acid

Downstream raw materials:

1-(3-cyclopentyl-1-tricyclo[3.3.1.1^3,7] decyl)-N¹-phenyl-1,2-ethanediamine

3-cyclopentyl-N-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanamine

1-cyclohexyl-5-(3-cyclopentyl-1-tricyclo[3.3.1.1^3,7]decyl)-4,5-dihydro-1H-imidazole

1-cyclohexyl-5-(3-cyclopentyl-1-tricyclo[3.3.1.1^3,7]decyl)-4,5-dihydro-1H-imidazole hydrochloride