Technology Process of 1,3,5,6-tetramethoxy-4-(4-(trifluoromethyl)phenyl)-9H-xanthen-9-one
There total 4 articles about 1,3,5,6-tetramethoxy-4-(4-(trifluoromethyl)phenyl)-9H-xanthen-9-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-iodo-1,3,5,6-tetramethoxy-9H-xanthen-9-one;
With
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane;
at 20 ℃;
for 0.166667h;
4-trifluoromethylphenylboronic acid;
With
sodium carbonate;
In
1,2-dimethoxyethane; water;
for 18h;
Reflux;
DOI:10.1016/j.ejmech.2013.08.020
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / diethyl ether / 8 h / 20 °C
2.1: pyridine; tetramethylammonium hydroxide / water / 36 h / Reflux
3.1: 20 °C / Inert atmosphere
4.1: tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 0.17 h / 20 °C
4.2: 18 h / Reflux
With
pyridine; aluminum (III) chloride; tetrakis(triphenylphosphine) palladium(0); tetramethylammonium hydroxide;
In
1,2-dimethoxyethane; diethyl ether; water;
4.1: |Suzuki Coupling / 4.2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.08.020
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine; tetramethylammonium hydroxide / water / 36 h / Reflux
2.1: 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 0.17 h / 20 °C
3.2: 18 h / Reflux
With
pyridine; tetrakis(triphenylphosphine) palladium(0); tetramethylammonium hydroxide;
In
1,2-dimethoxyethane; water;
3.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.08.020
