3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide

Base Information

Chemical Name:3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide
CAS No.:1065175-72-5
Molecular Formula:C₂₀H₂₀N₂O₃S
Molecular Weight:368.456
Hs Code.:

Synonyms:3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide

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Chemical Property of 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide

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Technology Process of 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide

There total 19 articles about 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1065181-82-9
5-bromo-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide

: 98-80-6
phenylboronic acid

: 1065175-72-5
3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 150 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 143262-10-6
1-(tert-butoxycarbonyl)indoline

: 1065175-72-5
3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; cyclohexane / 1.67 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice

1.2: 1 h / -78 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / 16 h / 20 °C / Inert atmosphere

4.1: manganese(IV) oxide / tetrahydrofuran / 20 °C / Inert atmosphere

5.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 °C / Inert atmosphere

5.2: 15 h / 20 °C / Inert atmosphere

6.1: dmap / tetrahydrofuran; acetonitrile / 4.5 h / 20 °C / Inert atmosphere

7.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / acetonitrile / 0 - 20 °C / Inert atmosphere

8.1: sodium hydroxide / methanol; water / 1.5 h / 85 °C / Inert atmosphere; Reflux

8.2: pH 1

9.1: ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed

10.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

With dmap; manganese(IV) oxide; N-Bromosuccinimide; N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; ammonia; sec.-butyllithium; urea hydrogen peroxide adduct; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; trifluoroacetic anhydride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1065181-79-4
5-bromo-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxylic acid

: 1065175-72-5
3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

With ammonia; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;