(E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione

Base Information

• Chemical Name: (E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione
• CAS No.: 1206819-04-6
• Molecular Formula: C₁₄H₁₅N₃O₂
• Molecular Weight: 257.292

Synonyms:(E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione

Chemical Property of (E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione

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Technology Process of (E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione

There total 1 articles about (E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-toluidine (106-49-0,12221-03-3) + 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde (4869-46-9) → (E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione (1206819-04-6)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; for 1.5h; Redflux;

DOI:10.1002/jhet.284

Reference yield:

(E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione (1206819-04-6) + N-hydroxy-4-methylbenzenecarboximidoyl chloride (36288-37-6) → 1,3-dimethyl-5-[3,4-bis(4-methylphenyl)-4,5-dihydro-1,2,4-oxadiazol-5-yl]-1,3-dimethyl-1H,3H-pyrimidine-2,4-dione (1206819-36-4)

Guidance literature:

With triethylamine; In chloroform; for 2.5h; Reflux;

DOI:10.1002/jhet.284

Reference yield:

(E)-1,3-dimethyl-5-[(4-methylphenylimino)methyl]-1H,3H-pyrimidine-2,4-dione (1206819-04-6) + 4-chlorobenzohydroximoyl chloride (28123-63-9) → 5-[3-(4-chlorophenyl)-4-(4-methylphenyl)-4,5-dihydro-1,2,4-oxadiazol-5-yl]-1,3-dimethyl-1H,3H-pyrimidine-2,4-dione (1206819-28-4)

Guidance literature:

With triethylamine; In chloroform; for 2h; Reflux;

DOI:10.1002/jhet.284

upstream raw materials:

p-toluidine

1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

Downstream raw materials:

1,3-dimethyl-5-[3,4-bis(4-methylphenyl)-4,5-dihydro-1,2,4-oxadiazol-5-yl]-1,3-dimethyl-1H,3H-pyrimidine-2,4-dione

5-[3-(4-chlorophenyl)-4-(4-methylphenyl)-4,5-dihydro-1,2,4-oxadiazol-5-yl]-1,3-dimethyl-1H,3H-pyrimidine-2,4-dione

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