C₂₄H₁₅F₃N₆O₂

Base Information

Chemical Name:C₂₄H₁₅F₃N₆O₂
CAS No.:1428155-60-5
Molecular Formula:C₂₄H₁₅F₃N₆O₂
Molecular Weight:476.417
Hs Code.:

C<sub>24</sub>H<sub>15</sub>F<sub>3</sub>N<sub>6</sub>O<sub>2</sub>

Synonyms:C₂₄H₁₅F₃N₆O₂

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Chemical Property of C₂₄H₁₅F₃N₆O₂

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Technology Process of C₂₄H₁₅F₃N₆O₂

There total 9 articles about C₂₄H₁₅F₃N₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1428155-51-4
2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

: 1428155-60-5
C₂₄H₁₅F₃N₆O₂

Guidance literature:: With trifluoroacetic acid; In water; acetonitrile; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1428155-60-5
C₂₄H₁₅F₃N₆O₂

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 15 h / 100 °C / Inert atmosphere; Sealed tube

2: ammonium chloride; iron / water; ethanol / 2 h / 90 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4: trifluoroacetic acid / water; acetonitrile / 3 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 609-71-2
2-hydroxy-3-carboxypyridine

: 1428155-60-5
C₂₄H₁₅F₃N₆O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane / 4 h / 75 °C

2.1: 12 h / 20 °C

3.1: ethyl 2-oxocyclohexane carboxylate; caesium carbonate; copper(I) bromide / dimethyl sulfoxide / 18 h / 60 °C / Sealed tube

4.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

4.2: pH 2 - 3

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / water; acetonitrile / 3 h / 0 - 20 °C

With thionyl chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; ethyl 2-oxocyclohexane carboxylate; HATU; trifluoroacetic acid; copper(I) bromide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.ejmech.2012.06.005