(4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone

Base Information

Chemical Name:(4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone
CAS No.:195607-06-8
Molecular Formula:C₂₃H₂₈N₂O₅S₂
Molecular Weight:476.618
Hs Code.:

Synonyms:(4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone

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Chemical Property of (4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone

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Technology Process of (4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone

There total 7 articles about (4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 195607-12-6
(S)-2-(Bis-ethylsulfanyl-methyl)-azetidine

: 195607-06-8
(4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone

Guidance literature:: DOI:10.1016/S0040-4039(97)01297-5

Reference yield:

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 195607-06-8
(4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N

2: SOCl₂

3: 78 percent / lithium borohydride / tetrahydrofuran / 0 - 20 °C

4: 85 percent / O-iodoxybenzoic acid / dimethylsulfoxide / 0.5 h / Ambient temperature

5: TMSCl / CHCl₃ / 12 h / Ambient temperature

With lithium borohydride; chloro-trimethyl-silane; thionyl chloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; chloroform; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(97)01297-5

Reference yield:

: 195607-11-5
(S)-2-(Bis-ethylsulfanyl-methyl)-azetidine-1-carboxylic acid benzyl ester

: 195607-06-8
(4-Benzyloxy-5-methoxy-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-azetidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / TMS-I / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 86 percent

With trimethylsilyl iodide; In dichloromethane;
DOI:10.1016/S0040-4039(97)01297-5