S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane

Base Information

Chemical Name:S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane
CAS No.:914955-88-7
Molecular Formula:C₂₅H₂₇F₂NO₃
Molecular Weight:427.491
Hs Code.:

Synonyms:S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane

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Technology Process of S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane

There total 4 articles about S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 914955-86-5
S-(+)-2β-formyl-3α-[bis(4-fluorophenyl)methoxy]tropane

: 5927-18-4
trimethyl phosphonoacetate

: 914955-88-7
S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; lithium chloride; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1021/jm060762q

Reference yield:

: 156774-35-5
O 620

: 914955-88-7
S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

2: 98 percent / oxalyl chloride; triethylamine; DMSO / CH₂Cl₂ / -78 - -20 °C

3: 86 percent / LiCl; N,N-diisopropylethylamine / acetonitrile / 24 h / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In diethyl ether; dichloromethane; acetonitrile; 2: Swern oxidation / 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jm060762q

Reference yield:

: 914955-85-4
S-(+)-2β-hydroxymethyl-3α-[bis(4-fluorophenyl)methoxy]tropane

: 914955-88-7
S-(+)-2β-(2'-(methoxycarbonyl)eth-1'-enyl)-3α-[bis(4-fluorophenyl)methoxy]tropane

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / oxalyl chloride; triethylamine; DMSO / CH₂Cl₂ / -78 - -20 °C

2: 86 percent / LiCl; N,N-diisopropylethylamine / acetonitrile / 24 h / 20 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In dichloromethane; acetonitrile; 1: Swern oxidation / 2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jm060762q