hexahydrocyclopenta[c]pyrrol-5(1H)-one

Base Information

• Chemical Name: hexahydrocyclopenta[c]pyrrol-5(1H)-one
• CAS No.: 96896-09-2
• Molecular Formula: C7H11NO
• Molecular Weight: 125.17
• Mol file: 96896-09-2.mol

Synonyms:hexahydrocyclopenta[c]pyrrol-5(1H)-one

Chemical Property of hexahydrocyclopenta[c]pyrrol-5(1H)-one

Chemical Property:

• Boiling Point: 225.1 °C at 760 mmHg
• Flash Point: 106.5 °C
• PSA: 29.10000
• Density: 1.083 g/cm³
• LogP: 0.57790
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(3AR,6aS)-Octahydrocyclopenta[c]pyrrole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hexahydrocyclopenta[c]pyrrol-5(1H)-one

There total 1 articles about hexahydrocyclopenta[c]pyrrol-5(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3aR,6aS)-tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (146231-54-1) → (3aR,6aS)-hexahydrocyclopenta[c]pyrrol-5(1H)-one (96896-09-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃;

DOI:10.1016/j.bmcl.2010.04.120

Reference yield: 94.4%

di-tert-butyl dicarbonate (24424-99-5) + (3aR,6aS)-hexahydrocyclopenta[c]pyrrol-5(1H)-one (96896-09-2) → (3aR,6aS)-tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (146231-54-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 54.9%

(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-5(1H)-one (96896-09-2) + benzyl chloroformate (501-53-1,94274-21-2) → (3aR,6aS)-benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (1217315-21-3,148404-29-9)

Guidance literature:

With triethylamine; In dichloromethane; at 30 ℃; for 3h; Cooling with ice;

upstream raw materials:

(3aR,6aS)-tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

Downstream raw materials:

(3aR,6aS)-benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

(3aR,6aS)-tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate