(E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

Base Information

Chemical Name:(E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate
CAS No.:1440161-52-3
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

Synonyms:(E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

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Chemical Property of (E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

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Technology Process of (E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

There total 4 articles about (E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1440161-49-8
(E)-2-formyl-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

: 74-88-4
methyl iodide

: 1440161-52-3
(E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

Guidance literature:: methyl iodide; With magnesium; In diethyl ether; Inert atmosphere; Reflux;

(E)-2-formyl-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate; In diethyl ether; at 0 ℃; for 3h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2013.04.086

Reference yield:

: 88-10-8
N,N-diethylcarbamyl chloride

: 1440161-52-3
(E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 12 h / 100 °C

2.1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.08 h / -90 °C / Inert atmosphere

2.2: 6 h / -90 °C / Inert atmosphere

3.1: magnesium / diethyl ether / Inert atmosphere; Reflux

3.2: 3 h / 0 °C / Inert atmosphere; Reflux

With pyridine; N,N,N,N,-tetramethylethylenediamine; magnesium; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tet.2013.04.086

Reference yield:

: 1440161-46-5
(E)-2-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

: 1440161-52-3
(E)-2-(1-hydroxyethyl)-6-methoxy-4-(prop-1-enyl)phenyl N,N'-diethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.08 h / -90 °C / Inert atmosphere

1.2: 6 h / -90 °C / Inert atmosphere

2.1: magnesium / diethyl ether / Inert atmosphere; Reflux

2.2: 3 h / 0 °C / Inert atmosphere; Reflux

With N,N,N,N,-tetramethylethylenediamine; magnesium; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tet.2013.04.086