1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: 1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
• CAS No.: 405296-87-9
• Molecular Formula: C₃₄H₅₆N₄O₇
• Molecular Weight: 632.841

Synonyms:1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Chemical Property of 1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Chemical Property:

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Technology Process of 1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

There total 3 articles about 1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

α-bromoacetophenone (70-11-1) + 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) → 1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (405296-87-9)

Guidance literature:

With potassium carbonate; In acetonitrile; for 3h; Inert atmosphere;

DOI:10.1039/c8cc08556k

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → 1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (405296-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / potassium carbonate / CHCl₃ / 72 h / 20 °C

2: 58 percent / potassium carbonate; KI / acetonitrile / 96 h / Heating

With potassium carbonate; potassium iodide; In chloroform; acetonitrile;

DOI:10.1039/b105966c

Reference yield:

1,4,7,10-tetraazacyclododecan (294-90-6) → 1-(2-oxo-2-phenylethyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (405296-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / potassium carbonate / CHCl₃ / 72 h / 20 °C

2: 58 percent / potassium carbonate; KI / acetonitrile / 96 h / Heating

With potassium carbonate; potassium iodide; In chloroform; acetonitrile;

DOI:10.1039/b105966c

upstream raw materials:

α-bromoacetophenone

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

bromoacetic acid tert-butyl ester

1,4,7,10-tetraazacyclododecan

Downstream raw materials:

2,2’,2’‘-(10-(2-oxo-2-phenylethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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