trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene

Base Information

• Chemical Name: trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene
• CAS No.: 132205-81-3
• Molecular Formula: C₂₀H₁₉NO
• Molecular Weight: 289.377
• Mol file: 132205-81-3.mol

Synonyms:trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene

Chemical Property of trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene

There total 4 articles about trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

1-benzyl-1H-pyrrole-2-carbaldehyde (18159-24-5) + dimethyl phosphonate (132205-80-2,62456-45-5) → trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene (132205-81-3)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; for 2h;

DOI:10.1021/jo00006a052

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) → trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene (132205-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 50 percent sodium hydroxide / 2.) tetrabutylammonium iodide / 1.) benzene, 2.) reflux, 24 h

2: 90.5 percent / potassium tert-butoxide / dimethylformamide / 2 h

With sodium hydroxide; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00006a052

Reference yield:

benzyl bromide (100-39-0) → trans-1-<2-(1-benzyl-1H-pyrrol-2-yl)-1-methoxyethenyl>benzene (132205-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 50 percent sodium hydroxide / 2.) tetrabutylammonium iodide / 1.) benzene, 2.) reflux, 24 h

2: 90.5 percent / potassium tert-butoxide / dimethylformamide / 2 h

With sodium hydroxide; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00006a052

upstream raw materials:

1-benzyl-1H-pyrrole-2-carbaldehyde

dimethyl phosphonate

2-pyrrole aldehyde

benzaldehyde dimethyl acetal

Downstream raw materials:

5-methoxy-3-benzyl-3H-benzindole