9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine

Base Information

• Chemical Name: 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine
• CAS No.: 76988-73-3
• Molecular Formula: C₁₈H₁₃Cl₂N₃
• Molecular Weight: 342.227
• Mol file: 76988-73-3.mol

Synonyms:9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine

Chemical Property of 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine

There total 3 articles about 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-39-1) → 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine (76988-73-3)

Guidance literature:

With acetic acid; zinc; In dichloromethane; at -30 ℃; for 2h;

DOI:10.1021/jm00365a009

Reference yield:

8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one (76049-70-2) → 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine (76988-73-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / dimethylformamide / 2 h / 80 - 85 °C

2: 90 percent / formamide / 16 h / 100 °C

3: 5 g / Zn, CH₃COOH / CH₂Cl₂ / 2 h / -30 °C

With acetic acid; zinc; In dichloromethane; formamide; N,N-dimethyl-formamide;

DOI:10.1021/jm00365a008

Reference yield:

8-Chloro-1-(2-chlorophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]-5H-2-benzazepin-5-one (58582-31-3) → 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine (76988-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / formamide / 16 h / 100 °C

2: 5 g / Zn, CH₃COOH / CH₂Cl₂ / 2 h / -30 °C

With acetic acid; zinc; In dichloromethane; formamide;

DOI:10.1021/jm00365a008

upstream raw materials:

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine

8-chloro-1-(2-chlorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one

8-Chloro-1-(2-chlorophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]-5H-2-benzazepin-5-one

Downstream raw materials:

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-<(4-methylphenyl)sulfonyl>-5H-pyrimido<5,4-d><2>benzazepine

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine 3-oxide

5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime