4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate

Base Information

Chemical Name:4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate
CAS No.:1069136-75-9
Molecular Formula:C₂₈H₃₁Cl₂N₃O₄S
Molecular Weight:576.544
Hs Code.:

Synonyms:4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate

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Chemical Property of 4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate

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Technology Process of 4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate

There total 9 articles about 4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 932739-13-4
1-(2,4-dichlorophenyl)-2-(4-hydroxyphenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

: 10147-36-1
n-propanesulfonyl chloride

: 1069136-75-9
4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 10.75h;

Reference yield:

: 1001018-36-5
4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

: 1069136-75-9
4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / toluene / 2 h / 60 °C

2: triethylamine / dichloromethane / 10.75 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 71365-42-9
3-(piperidin-1-ylamino)-propionic acid methyl ester

: 1069136-75-9
4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenylpropane-1-sulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2.1: caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 48 h / 80 °C / Heating / reflux

3.1: acetic acid / water / 1 h / Heating / reflux

4.1: 2-methyltetrahydrofuran / 22 h / Heating / reflux

5.1: sodium hydride / tetrahydrofuran / 1.25 h / 0 - 5 °C

5.2: 0.25 h

6.1: trifluoroacetic acid / toluene / 2 h / 60 °C

7.1: triethylamine / dichloromethane / 10.75 h / 0 - 20 °C

With sodium hydride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;