4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

Base Information

Chemical Name:4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one
CAS No.:1001018-36-5
Molecular Formula:C₂₉H₃₅Cl₂N₃O₄
Molecular Weight:560.521
Hs Code.:

Synonyms:4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

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Chemical Property of 4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

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Technology Process of 4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

There total 8 articles about 4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1001018-34-3
2-bromo-1-[4-(1-ethoxyethoxy)phenyl]propan-1-one

: 1001018-35-4
4-[(2,4-dichlorophenyl)amino]-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

: 1001018-36-5
4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

Guidance literature:: 4-[(2,4-dichlorophenyl)amino]-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one; With sodium hydride; In tetrahydrofuran; at 0 - 5 ℃; for 1.25h;

2-bromo-1-[4-(1-ethoxyethoxy)phenyl]propan-1-one; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; for 0.25h;

Reference yield:

: 71365-42-9
3-(piperidin-1-ylamino)-propionic acid methyl ester

: 1001018-36-5
4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2.1: caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 48 h / 80 °C / Heating / reflux

3.1: acetic acid / water / 1 h / Heating / reflux

4.1: 2-methyltetrahydrofuran / 22 h / Heating / reflux

5.1: sodium hydride / tetrahydrofuran / 1.25 h / 0 - 5 °C

5.2: 0.25 h

With sodium hydride; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 503842-30-6
N-(2-methoxycarbonylethyl)-N-piperidin-1-yl-malonamic acid ethyl ester

: 1001018-36-5
4-[(2,4-dichlorophenyl)amino]-3-{2-[4-(1-ethoxyethoxy)phenyl]-1-methyl-2-oxoethyl}-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 48 h / 80 °C / Heating / reflux

2.1: acetic acid / water / 1 h / Heating / reflux

3.1: 2-methyltetrahydrofuran / 22 h / Heating / reflux

4.1: sodium hydride / tetrahydrofuran / 1.25 h / 0 - 5 °C

4.2: 0.25 h

With sodium hydride; caesium carbonate; acetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide;