benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

Base Information

Chemical Name:benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate
CAS No.:1532520-66-3
Molecular Formula:C₂₈H₁₉NO₄
Molecular Weight:433.463
Hs Code.:

Synonyms:benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

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Chemical Property of benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

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Technology Process of benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

There total 3 articles about benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1458638-00-0
benzyl 2-(3,4-dihydroisoquinolin-2(1H)-yl)acetate

: 130-15-4
[1,4]naphthoquinone

: 1532520-66-3
benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

Guidance literature:: With tert.-butylhydroperoxide; potassium iodide; In water; N,N-dimethyl-formamide; at 80 ℃; for 9h; Green chemistry;
DOI:10.1039/c4ra03455d

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1532520-66-3
benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran / 20 °C

2: diethylazodicarboxylate / 1,2-dichloro-ethane / 12 h / 20 °C

With sodium carbonate; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/acs.joc.0c01567

Reference yield:

: 5437-45-6
Benzyl bromoacetate

: 1532520-66-3
benzyl 2,3-dimethoxy-9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran / 20 °C

2: diethylazodicarboxylate / 1,2-dichloro-ethane / 12 h / 20 °C

With sodium carbonate; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/acs.joc.0c01567