7-bromo-8-methoxy-3-methyl-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Base Information

Chemical Name:7-bromo-8-methoxy-3-methyl-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine
CAS No.:136247-21-7
Molecular Formula:C₁₈H₁₉BrN₂O₃
Molecular Weight:391.264
Hs Code.:
DSSTox Substance ID:DTXSID601134880

Synonyms:SCHEMBL3666853;WHRWHCNKOIRDLB-UHFFFAOYSA-N;DTXSID601134880;7-bromo-8-methoxy-3-methyl-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine;136247-21-7;7-Bromo-2,3,4,5-tetrahydro-8-methoxy-3-methyl-1-(4-nitrophenyl)-1H-3-benzazepine;8-methoxy-7-bromo-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Suppliers and Price of 7-bromo-8-methoxy-3-methyl-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-bromo-8-methoxy-3-methyl-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:390.05791
Heavy Atom Count:24
Complexity:437

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCC2=CC(=C(C=C2C(C1)C3=CC=C(C=C3)[N+](=O)[O-])OC)Br

Technology Process of 7-bromo-8-methoxy-3-methyl-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

There total 1 articles about 7-bromo-8-methoxy-3-methyl-1-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 116234-47-0
8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 136247-21-7
7-bromo-8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With bromine; acetic acid; at 60 ℃; for 3h;
DOI:10.1021/jm00115a012

Reference yield: 70.0%

: 136247-21-7
7-bromo-8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 136247-22-8
7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With nickel; hydrazine hydrate; In ethanol; at 50 ℃;
DOI:10.1021/jm00115a012

Reference yield:

: 136247-21-7
7-bromo-8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 136247-23-9
SKF 83566-NH₂

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / hydrazine hydrate, Raney Ni / ethanol / 50 °C

2: 62 percent / BBr₃ / CH₂Cl₂; hexane / 1.) -70 deg C, 1 h, 2.) RT, 3 h

With boron tribromide; nickel; hydrazine hydrate; In ethanol; hexane; dichloromethane;
DOI:10.1021/jm00115a012