7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

• Chemical Name: 7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
• CAS No.: 136247-22-8
• Molecular Formula: C₁₈H₂₁BrN₂O
• Molecular Weight: 361.282

Synonyms:7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property of 7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property:

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Technology Process of 7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 2 articles about 7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-bromo-8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (136247-21-7) → 7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (136247-22-8)

Guidance literature:

With nickel; hydrazine hydrate; In ethanol; at 50 ℃;

DOI:10.1021/jm00115a012

Reference yield:

8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (116234-47-0) → 7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (136247-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / Br₂, AcOH / 3 h / 60 °C

2: 70 percent / hydrazine hydrate, Raney Ni / ethanol / 50 °C

With bromine; nickel; hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1021/jm00115a012

Reference yield: 62.0%

7-bromo-8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (136247-22-8) → SKF 83566-NH2 (136247-23-9)

Guidance literature:

With boron tribromide; In hexane; dichloromethane; 1.) -70 deg C, 1 h, 2.) RT, 3 h;

DOI:10.1021/jm00115a012

upstream raw materials:

7-bromo-8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Downstream raw materials:

SKF 83566-NH₂

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