(1R,2R)-3-O-(tert-butyldiphenylsilyl)-1-(2-thiazolyl)-1,2,3-propanetriol

Base Information

Chemical Name:(1R,2R)-3-O-(tert-butyldiphenylsilyl)-1-(2-thiazolyl)-1,2,3-propanetriol
CAS No.:141873-72-5
Molecular Formula:C₂₂H₂₇NO₃SSi
Molecular Weight:413.613
Hs Code.:

Synonyms:(1R,2R)-3-O-(tert-butyldiphenylsilyl)-1-(2-thiazolyl)-1,2,3-propanetriol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-3-O-(tert-butyldiphenylsilyl)-1-(2-thiazolyl)-1,2,3-propanetriol

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Technology Process of (1R,2R)-3-O-(tert-butyldiphenylsilyl)-1-(2-thiazolyl)-1,2,3-propanetriol

There total 2 articles about (1R,2R)-3-O-(tert-butyldiphenylsilyl)-1-(2-thiazolyl)-1,2,3-propanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 141873-71-4
(1R,2R)-1-(2-thiazolyl)-1,2,3-propanetriol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 141873-72-5
(1R,2R)-3-O-(tert-butyldiphenylsilyl)-1-(2-thiazolyl)-1,2,3-propanetriol

Guidance literature:: With dmap; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1055/s-1992-34166

Reference yield:

: 103795-10-4
(2R,3R)-1,2-O-Isopropylidene-3-(2-thiazolyl)-1,2,3-propanetriol

: 141873-72-5
(1R,2R)-3-O-(tert-butyldiphenylsilyl)-1-(2-thiazolyl)-1,2,3-propanetriol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 90percent AcOH / H₂O / 0.5 h / 90 °C

2: 96 percent / Et₃N, DMAP / dimethylformamide / 16 h / 25 °C

With dmap; acetic acid; triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.1055/s-1992-34166