6-Bromo-2-pyridinemethanamine

Base Information

• Chemical Name: 6-Bromo-2-pyridinemethanamine
• CAS No.: 188637-63-0
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.039
• Hs Code.: 2933399990
• Mol file: 188637-63-0.mol

Synonyms:(6-Bromopyridin-2-yl)methanamine;2-(Aminomethyl)-6-bromopyridine;6-Bromo-2-aminomethylpyridine;[(6-Bromopyridin-2-yl)methyl]amine;

Chemical Property of 6-Bromo-2-pyridinemethanamine

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.597
• Boiling Point: 266.853 °C at 760 mmHg
• PKA: 8.42±0.39(Predicted)
• Flash Point: 115.189 °C
• PSA: 38.91000
• Density: 1.574 g/cm³
• LogP: 2.00310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

(6-bromopyridin-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-2-pyridinemethanamine

There total 6 articles about 6-Bromo-2-pyridinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-[(6-bromopyridin-2-yl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione (521917-57-7) → (6-bromopyridin-2-yl)methanamine (188637-63-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 70 ℃;

DOI:10.1016/j.bmcl.2011.09.111

Reference yield:

6-bromo-2-pyridinecarbaldehyde (34160-40-2) → bis-(6-bromo-pyridin-2-ylmethyl)-amine (1265139-77-2) + (6-bromopyridin-2-yl)methanamine (188637-63-0)

Guidance literature:

6-bromo-2-pyridinecarbaldehyde; With polymer-bound 4-methoxybenzhydrylamine; sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 48h;

With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2007.01.077

Reference yield:

Br(1-)*C12H17BrN5(1+) → (6-bromopyridin-2-yl)methanamine (188637-63-0)

Guidance literature:

Br^(1-)*C₁₂H₁₇BrN₅⁽¹⁺⁾; With hydrogenchloride; In ethanol; water; at 90 ℃; for 14h;

In ethanol; water; pH=12;

upstream raw materials:

6-bromo-2-pyridinecarbaldehyde

2-[(6-bromopyridin-2-yl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione

2-bromo-6-(hydroxymethyl)pyridine

2-bromo-6-(chloromethyl)pyridine

Downstream raw materials:

7-bromo-[1,2,3]triazolo[1,5-a]pyridine

2-bromo-N-(5-{6-[2-(2-nitrobenzenesulfonylamino)methyl]pyridin-2-yl}hexyl) acetamide

3-(2-nitrobenzenesulfonyl)-3,6,17-triazabicyclo[11,3,1]heptadeca-1⁽¹⁷⁾,13,15-trien-5-one

{2-[6-(5-cyanopentyl)pyridin-2-yl]methyl}-2-nitrobenzenesulfonamide

Refernces

• 1、 Pelletier, Guillaume,Charette, Andre B.. "Triflic anhydride mediated synthesis of imidazo[1,5-a]azines". supporting information. p. 2290 - 2293. Retrieved 2013/06/26.
• 2、 -. "ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS". Page/Page column 30. . Retrieved 2008/12/07.