4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure

Base Information

• Chemical Name: 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure
• CAS No.: 86768-10-7
• Molecular Formula: C₁₇H₁₀ClFN₂O₃
• Molecular Weight: 344.729
• Mol file: 86768-10-7.mol

Synonyms:4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure

Chemical Property of 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure

There total 4 articles about 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure-ethylester (86768-09-4) → 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure (86768-10-7)

Guidance literature:

With sodium hydroxide;

DOI:10.1002/ardp.19833160706

Reference yield:

(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (67382-35-8,28587-05-5) → 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure (86768-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 51.4 percent / Et₃N / CHCl₃ / Ambient temperature

2: 92.6 percent / NaOH

With sodium hydroxide; triethylamine; In chloroform;

DOI:10.1002/ardp.19833160706

Reference yield:

para-chloroacetophenone (99-91-2) → 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure (86768-10-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 2 h

2: 51.4 percent / Et₃N / CHCl₃ / Ambient temperature

3: 92.6 percent / NaOH

With sodium hydroxide; triethylamine; In chloroform;

DOI:10.1002/ardp.19833160706

upstream raw materials:

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure-ethylester

(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one

para-chloroacetophenone

2-Chlor-2-(4-fluorphenylhydrazono)-essigsaeure-ethylester

Downstream raw materials:

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

4-(4-Chlorbenzoyl)-3-diazoacetyl-1-(4-fluorphenyl)-pyrazol

4-(4-Chlor-α-hydroxy-benzyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure