4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid

Base Information

• Chemical Name: 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid
• CAS No.: 86768-11-8
• Molecular Formula: C₁₇H₉Cl₂FN₂O₂
• Molecular Weight: 363.175
• Mol file: 86768-11-8.mol

Synonyms:4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid

Chemical Property of 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid

There total 5 articles about 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure (86768-10-7) → 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid (86768-11-8)

Guidance literature:

With thionyl chloride; In chloroform; for 3h; Heating;

DOI:10.1002/ardp.19833160706

Reference yield:

(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (67382-35-8,28587-05-5) → 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid (86768-11-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 51.4 percent / Et₃N / CHCl₃ / Ambient temperature

2: 92.6 percent / NaOH

3: 93.7 percent / SOCl₂ / CHCl₃ / 3 h / Heating

With sodium hydroxide; thionyl chloride; triethylamine; In chloroform;

DOI:10.1002/ardp.19833160706

Reference yield:

para-chloroacetophenone (99-91-2) → 4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeurechlorid (86768-11-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / 2 h

2: 51.4 percent / Et₃N / CHCl₃ / Ambient temperature

3: 92.6 percent / NaOH

4: 93.7 percent / SOCl₂ / CHCl₃ / 3 h / Heating

With sodium hydroxide; thionyl chloride; triethylamine; In chloroform;

DOI:10.1002/ardp.19833160706

upstream raw materials:

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure

(2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one

para-chloroacetophenone

2-Chlor-2-(4-fluorphenylhydrazono)-essigsaeure-ethylester

Downstream raw materials:

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure-tert.butylester

4-(4-Chlor-α-hydroxy-benzyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure

4-(4-Chlorbenzoyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure

4-(4-Chlorbenzyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure