6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide

Base Information

Chemical Name:6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide
CAS No.:1416216-50-6
Molecular Formula:C₂₂H₁₉N₃O₄S
Molecular Weight:421.477
Hs Code.:

Synonyms:6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide

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Chemical Property of 6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide

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Technology Process of 6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide

There total 3 articles about 6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 426219-35-4
6-bromo-N-methyl-2-naphthamide

: 1416216-56-2
1-(phenylsulfonyl)-4-formyl-1H-imidazole

: 1416216-50-6
6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide

Guidance literature:: With n-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; hexane; at -30 ℃; Inert atmosphere;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1416216-50-6
6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile; tetrahydrofuran / 30 °C

2: n-butyllithium; isopropylmagnesium chloride / hexane; tetrahydrofuran / -30 °C / Inert atmosphere

With n-butyllithium; isopropylmagnesium chloride; triethylamine; In tetrahydrofuran; hexane; acetonitrile;

Reference yield:

: 5773-80-8
6-bromo-2-naphthoic acid

: 1416216-50-6
6-(hydroxy(1-(phenylsulfonyl)-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 1 h / 45 - 50 °C

1.2: 1 h / 10 - 25 °C

2.1: n-butyllithium; isopropylmagnesium chloride / hexane; tetrahydrofuran / -30 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; isopropylmagnesium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; toluene;