Technology Process of 4,6-difluoro-5-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-1H-indole-3-carbaldehyde
There total 10 articles about 4,6-difluoro-5-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-1H-indole-3-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate;
In
ethanol; water; toluene;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid; N-iodo-succinimide / 2 h / 20 °C
2.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 2.17 h / 20 °C
2.2: 88 h / 20 - 50 °C
3.1: copper(l) iodide / N,N-dimethyl-formamide / 3.75 h / 110 °C / Sealed tube
4.1: N-(chloromethylidene) N-methylmethanaminium; sodium hydroxide / water / 1 h / 20 °C
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; ethanol; toluene / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; copper(l) iodide; N-(chloromethylidene) N-methylmethanaminium; potassium carbonate; acetic acid; triethylamine; sodium hydroxide;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 2.17 h / 20 °C
1.2: 88 h / 20 - 50 °C
2.1: copper(l) iodide / N,N-dimethyl-formamide / 3.75 h / 110 °C / Sealed tube
3.1: N-(chloromethylidene) N-methylmethanaminium; sodium hydroxide / water / 1 h / 20 °C
4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; ethanol; toluene / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; N-(chloromethylidene) N-methylmethanaminium; potassium carbonate; triethylamine; sodium hydroxide;
In
ethanol; water; N,N-dimethyl-formamide; toluene;