N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide

Base Information

Chemical Name:N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide
CAS No.:725233-12-5
Molecular Formula:C₂₂H₂₃N₃O₂S
Molecular Weight:393.51
Hs Code.:

Synonyms:N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide

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Chemical Property of N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide

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Technology Process of N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide

There total 3 articles about N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 74-88-4
methyl iodide

: 355134-04-2
N-benzyl-N-[5-(1H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide

: 725233-12-5
N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide

: 258527-79-6
N-benzyl-N-[5-(1-methyl-1H-imidazol-4-yl)-7,8-dihydro-1-naphthalenyl]methanesulfonamide

Guidance literature:: N-benzyl-N-[5-(1H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; for 0.25h;

methyl iodide; In N,N-dimethyl-formamide; for 1h;
DOI:10.1021/jm030551a

Reference yield:

: 725233-09-0
N-benzyl-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamide

: 725233-12-5
N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: EtMgBr / CH₂Cl₂; diethyl ether / 0.5 h

1.2: CH₂Cl₂; diethyl ether / 20 °C

2.1: 1.1 g / aq. HCl / 7 h / Heating

3.1: NaH / dimethylformamide / 0.25 h

3.2: 24 percent / dimethylformamide / 1 h

With hydrogenchloride; ethylmagnesium bromide; sodium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030551a

Reference yield:

: 4-[5-(benzyl-methanesulfonyl-amino)-1-hydroxy-1,2,3,4-tetrahydro-naphthalen-1-yl]-imidazole-1-sulfonic acid dimethylamide

: 725233-12-5
N-benzyl-N-[5-(3-methyl-3H-imidazol-4-yl)-7,8-dihydronaphthalen-1-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1.1 g / aq. HCl / 7 h / Heating

2.1: NaH / dimethylformamide / 0.25 h

2.2: 24 percent / dimethylformamide / 1 h

With hydrogenchloride; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm030551a