1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea

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Chemical Name:1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea
CAS No.:1346424-56-3
Molecular Formula:C₂₈H₃₅BrN₆O₂
Molecular Weight:567.529
Hs Code.:

Synonyms:1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea

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Chemical Property of 1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea

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Technology Process of 1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea

There total 5 articles about 1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 5-(aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine dihydrochloride

: 4-(5-bromopent-1-yn-1-yl)aniline methanesulfonate

: 1346424-56-3
1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea

Guidance literature:: 4-(5-bromopent-1-yn-1-yl)aniline methanesulfonate; With triethylamine; In dichloromethane;

bis(trichloromethyl) carbonate; 5-(aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine dihydrochloride; Cooling with ice;

Reference yield:

: 14267-92-6
1-chloro-4-pentyne

: 1346424-56-3
1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 55 °C / Inert atmosphere

2.1: lithium bromide / pentan-3-one / Reflux

3.1: tin(ll) chloride / dichloromethane; 1-methyl-pyrrolidin-2-one / 20 °C / Cooling with ice

4.1: triethylamine / dichloromethane

4.2: Cooling with ice

With copper(l) iodide; triethylamine; tin(ll) chloride; lithium bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; pentan-3-one;

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 1346424-56-3
1-(4-(5-bromopent-1-yn-1-yl)phenyl)-3-((1,6-diethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 55 °C / Inert atmosphere

2.1: lithium bromide / pentan-3-one / Reflux

3.1: tin(ll) chloride / dichloromethane; 1-methyl-pyrrolidin-2-one / 20 °C / Cooling with ice

4.1: triethylamine / dichloromethane

4.2: Cooling with ice

With copper(l) iodide; triethylamine; tin(ll) chloride; lithium bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; pentan-3-one;