N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide

Base Information

• Chemical Name: N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide
• CAS No.: 1621071-26-8
• Molecular Formula: C₂₂H₂₆N₆O₇
• Molecular Weight: 486.484
• Mol file: 1621071-26-8.mol

Synonyms:N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide

Chemical Property of N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide

There total 4 articles about N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-amino-1-(2-nitrophenyl)butan-1-ol (1621071-19-9) + 6-(7-nitrobenzofurazan-4-ylamino)hexanoic acid (88235-25-0) → N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide (1621071-26-8)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1039/c4ob00707g

Reference yield:

2-(4-hydroxy-4-(2-nitrophenyl)butyl)isoindoline-1,3-dione (1401067-58-0) → N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide (1621071-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; acetonitrile;

DOI:10.1039/c4ob00707g

Reference yield:

NBD chloride (10199-89-0) + 6-aminohexanoic acid (60-32-2,93208-38-9) → N-(4-hydroxy-4-(2-nitrophenyl)butyl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide (1621071-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / methanol / 3.5 h / 0 - 50 °C / Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; acetonitrile;

DOI:10.1039/c4ob00707g

upstream raw materials:

4-amino-1-(2-nitrophenyl)butan-1-ol

6-(7-nitrobenzofurazan-4-ylamino)hexanoic acid

NBD chloride

6-aminohexanoic acid