Technology Process of methyl (2R,4R)-4-<(benzyloxycarbonyl)amino>-2-hydroxy-5-methylhexanoate
There total 14 articles about methyl (2R,4R)-4-<(benzyloxycarbonyl)amino>-2-hydroxy-5-methylhexanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4R)-4-benzyloxycarbonylamino-5-methylhexanoic acid methyl ester;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
With
N-(benzenesulfonyl)-3-phenyloxaziridine;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
DOI:10.1021/ol048252i
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaBr; TEMPO; NaOCl / H2O; toluene; ethyl acetate / 4 h / 0 °C
2.1: 3.9 g / CH2Cl2 / 14 h / 0 - 20 °C
3.1: 80 percent / rac-BINAP; t-BuONa; CuCl / polymethylhydrosiloxane / toluene / 72 h / 20 °C
4.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
4.2: 66 percent / (+/-)-trans-2-(phenylsulfonyl)-3-phenyloxaziridine / tetrahydrofuran / 1 h / -78 °C
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hexamethyldisilazane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium bromide; copper(l) chloride; sodium t-butanolate;
polymethylhydrosiloxane;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
2.1: Wiitig olefination;
DOI:10.1021/ol048252i
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 3.9 g / CH2Cl2 / 14 h / 0 - 20 °C
2.1: 80 percent / rac-BINAP; t-BuONa; CuCl / polymethylhydrosiloxane / toluene / 72 h / 20 °C
3.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
3.2: 66 percent / (+/-)-trans-2-(phenylsulfonyl)-3-phenyloxaziridine / tetrahydrofuran / 1 h / -78 °C
With
sodium hexamethyldisilazane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; copper(l) chloride; sodium t-butanolate;
polymethylhydrosiloxane;
In
tetrahydrofuran; dichloromethane; toluene;
1.1: Wiitig olefination;
DOI:10.1021/ol048252i
