6216-65-5

Basic information

• Product Name: CBZ-L-VALINOL
• Synonyms: CBZ-L-VALINOL;N-CARBOBENZOXY-L-VALINOL;Z-VAL-OL;N-Benzyloxycarbonyl-L-valinol;Z-Valinol
• CAS NO: 6216-65-5
• Molecular Formula: C₁₃H₁₉NO₃
• Molecular Weight: 237.29
• Mol File: 6216-65-5.mol
• Article Data: 39

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: CBZ-L-VALINOL(CAS DataBase Reference)
• NIST Chemistry Reference: CBZ-L-VALINOL(6216-65-5)
• EPA Substance Registry System: CBZ-L-VALINOL(6216-65-5)

Safety Data

• Hazardous Substances Data: 6216-65-5(Hazardous Substances Data)

Usage

General Description

CBZ-L-VALINOL, also known as benzyl carboxybenzyl-D-valine, is a chemical compound often utilized in chemical research and drug development. It is typically used as a reagent to facilitate chemical reactions, particularly in the synthesis of various pharmaceuticals. The compound is distinguished by its molecular formula, C17H21NO3, and is recognized for its stability and effectiveness as a reagent in reactions that require stereospecific organic substances. However, as with any chemical reagent, the handling and usage of CBZ-L-VALINOL necessitate stringent safety protocols due to its potential hazard potential.

Upstream product

• 66866-64-6 (4S)-4-isopropyl-5-oxo-1,3-oxazolidine-3-carboxylic acid benzyl ester 
• 134306-34-6 N-(Benzyloxycarbonyl)valine methyl ester 
• 41445-88-9 Z-Val-OCO₂ⁱBu 
• 72-18-4 L-valine 
• 501-53-1 benzyl chloroformate 
• 2026-48-4 (S)-valinol 
• 91285-94-8 O-benzyl S-(pyridin-2-yl)carbonothioate 
• 119153-86-5 C₁₆H₂₁NO₆ 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 67729-33-3 C₁₈H₂₅NO₆ 
• 60-29-7 diethyl ether 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 138754-84-4 N-benzyloxycarbonyl-L-valinal 
• 24210-19-3 methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate 

Downstream Products

• 2026-48-4 (S)-valinol 
• 429669-62-5 [(1S)-1-(t-butyldiphenylsilyloxy)-2-methylpropyl]carbamic acid benzyl ester 
• 1087271-39-3 (S)-N-Cbz-2-isopropylaziridine 
• 1169199-22-7 Cbz-Val-ψ[CH2SO2]-F 
• 137719-71-2 (S)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl ethanethioate 
• 477808-39-2 (S)-2-benzyloxycarbonylamino-3-methylbutane-1-sulfonyl chloride 
• 1449512-60-0 (S)-(2-methyl-1-nitromethylpropyl)carbamic acid benzyl ester 
• 1638689-28-7 C₁₆H₂₀N₄O₄ 
• 1638689-57-2 C₂₆H₃₁N₅O₅ 
• 24294-83-5 2,5-bis(1-methylethyl)pyrazine 
• 137649-79-7 (4S,5R,4'S,5'R)-4,4'-Diisopropyl-3,3'-bis-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-[5,5']bioxazolidinyl-2,2'-dione 
• 137649-67-3 (3S,4R,5R,6S)-3,6-Bis-2,7-dimethyl-4,5-octanediol 
• 161709-21-3 [(1S,2S)-1-((S)-1-Hydroxymethyl-2-methyl-propylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester 
• 241149-80-4 (2'S,3'S)-methyl 2-[3-(benzyloxycarbonylamino)-2-hydroxy-4-methylpentyl]propenoate 

Relevant articles and documents

O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups

Amino groups are selectively protected in good yields by reaction with O-Alkyl S-(pyridin-2-yl)carbonothiolates in an appropriate solvent at room temperature in air. Even glucosamine, which contains multiple hydroxyl groups, is selectively N-protected in methanol.

Total synthesis of tubulysin U and N14-desacetoxytubulysin H

A concise and efficient procedure for the total synthesis of tubulysin U and N14-desacetoxytubulysin H has been developed with high stereoselectivity on a gram scale. This synthesis features an elegant cascade one-pot process to install the challenging th

Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)

Past studies have shown that it has been difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having potential for clinical development. In this study, we present a structure-activity relationship (SAR) study of a recently discovered new class of tetrahydroisoquinoline κ opioid receptor antagonists which led to (3R)-7-hydroxy-N-{(1S)-2-methyl-1-[(-4-methylpiperidine-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (12) (4-Me-PDTic). Compound 12 had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors, respectively. Calculated log BB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 12 will penetrate the brain, and pharmacokinetic studies in rats show that 12 does indeed penetrate the brain.