(2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol

Base Information

• Chemical Name: (2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol
• CAS No.: 214280-00-9
• Molecular Formula: C₂₆H₂₉ClN₄O₂SSi
• Molecular Weight: 525.146

Synonyms:(2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol

Chemical Property of (2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol

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Technology Process of (2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol

There total 3 articles about (2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

9-[(3S,4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine (206762-99-4) → (2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol (214280-00-9)

Guidance literature:

With boron trichloride; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1021/jo980667s

Reference yield:

6-chloropurine (87-42-3) → (2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol (214280-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 15 percent / PPh₃, DEAD / tetrahydrofuran / 21 h / Ambient temperature

2: 87 percent / BCl₃ / CH₂Cl₂ / 0.5 h / Ambient temperature

With boron trichloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo980667s

Reference yield:

(3S,4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-ol (174833-54-6) → (2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(6-chloro-purin-9-yl)-tetrahydro-thiophen-3-ol (214280-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 15 percent / PPh₃, DEAD / tetrahydrofuran / 21 h / Ambient temperature

2: 87 percent / BCl₃ / CH₂Cl₂ / 0.5 h / Ambient temperature

With boron trichloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo980667s

upstream raw materials:

9-[(3S,4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

6-chloropurine

(3S,4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-ol

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