2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

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Chemical Name:2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide
CAS No.:1334674-10-0
Molecular Formula:C₂₅H₃₄N₆O₃
Molecular Weight:466.583
Hs Code.:

Synonyms:2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

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Chemical Property of 2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

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Technology Process of 2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

There total 12 articles about 2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1334675-85-2
2-cyclohexyloxy-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

: 1334674-10-0
2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

Guidance literature:: With 18-crown-6 ether; cesium fluoride; In acetonitrile; at 20 ℃; for 72h; Reflux;

Reference yield:

: 124655-17-0
(R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

: 1334674-10-0
2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

2: dichloromethane / 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

4: potassium phosphate; copper(l) iodide; 8-quinolinol / 24 h / 120 °C / Inert atmosphere

5: cesium fluoride; 18-crown-6 ether / acetonitrile / 72 h / 20 °C / Reflux

With potassium phosphate; copper(l) iodide; 8-quinolinol; 18-crown-6 ether; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1334674-88-2
(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1334674-10-0
2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: Jones reagent / water; acetone / 0.25 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.2: 0 - 20 °C

3.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / 1,4-dioxane; water / 2.25 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

5.1: potassium phosphate; copper(l) iodide; 8-quinolinol / 24 h / 120 °C / Inert atmosphere

6.1: cesium fluoride; 18-crown-6 ether / acetonitrile / 72 h / 20 °C / Reflux

With sodium chlorite; potassium phosphate; potassium dihydrogenphosphate; copper(l) iodide; 8-quinolinol; Jones reagent; 18-crown-6 ether; aminosulfonic acid; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil;