3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

Base Information

• Chemical Name: 3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester
• CAS No.: 862202-03-7
• Molecular Formula: C₃₄H₄₈N₂O₁₂S
• Molecular Weight: 708.827

Synonyms:3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

Chemical Property of 3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

There total 12 articles about 3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate (879130-15-1) + allyl 4-oxobutanoate (285982-04-9) → 3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester (862202-03-7)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1246/cl.2005.800

Reference yield:

6-nitro-octane-1,5-diol → 3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester (862202-03-7)

Guidance literature:

Multi-step reaction with 10 steps

1: 4-(dimethylamino)pyridine / tetrahydrofuran / 1 h / 0 - 20 °C

2: 67 percent / DBU / tetrahydrofuran / 0 - 20 °C

3: N-iodosuccinimide / acetone / 1 h / 20 °C

4: toluene / 48 h / 20 °C

5: tetrahydrofuran / 1.5 h / Heating

6: DMAP / acetonitrile / 1 h / -40 - 20 °C

7: aq. HCl / methanol / 20 °C

8: iodine; Ph₃P; imidazole / acetonitrile / 1 h / 20 °C

9: sodium nitrite; phloroglucinol dihydrate / dimethylformamide / 7 h / 20 °C

10: 64 percent / KOH / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; dmap; potassium hydroxide; N-iodo-succinimide; 3,5-dihydroxyphenol; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium nitrite; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 2: Barton's method / 10: Henry reaction;

DOI:10.1246/cl.2005.800

Reference yield:

6-nitrooctane-1,5-diyl diacetate (862201-99-8) → 3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester (862202-03-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 67 percent / DBU / tetrahydrofuran / 0 - 20 °C

2: N-iodosuccinimide / acetone / 1 h / 20 °C

3: toluene / 48 h / 20 °C

4: tetrahydrofuran / 1.5 h / Heating

5: DMAP / acetonitrile / 1 h / -40 - 20 °C

6: aq. HCl / methanol / 20 °C

7: iodine; Ph₃P; imidazole / acetonitrile / 1 h / 20 °C

8: sodium nitrite; phloroglucinol dihydrate / dimethylformamide / 7 h / 20 °C

9: 64 percent / KOH / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; dmap; potassium hydroxide; N-iodo-succinimide; 3,5-dihydroxyphenol; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium nitrite; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 1: Barton's method / 9: Henry reaction;

DOI:10.1246/cl.2005.800

upstream raw materials:

di-t-butyl 4-ethyl-3-(4-nitrobutyl)-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

allyl 4-oxobutanoate

6-nitrooctane-1,5-diyl diacetate

t-butyl 3-(4-acetoxybutyl)-4-ethyl-1H-pyrrole-2-carboxylate

Downstream raw materials:

di-t-butyl 3-{3-[4-(2-allyloxycarbonylethyl)-5-(t-butoxycarbonyl)-1H-pyrrol-3-yl]propyl}-4-ethyl-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

di-t-butyl 3-{3-[4-(2-allyloxycarbonylethyl)-5-(t-butoxycarbonyl)-2-formyl-1H-pyrrol-3-yl]propyl}-4-ethyl-5-oxo-2-tosyl-1H-pyrrole-1,2(2H,5H)-dicarboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 862202-03-7 3-(7-allyloxycarbonyl-5-hydroxy-4-nitro-heptyl)-4-ethyl-5-oxo-2-(toluene-4-sulfonyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send