Argireline

Base Information

Chemical Name:Argireline
CAS No.:616204-22-9
Molecular Formula:C₃₄H₆₀N₁₄O₁₂S
Molecular Weight:889.003
Hs Code.:
European Community (EC) Number:801-648-4
Nikkaji Number:J2.053.030H
Wikipedia:Acetyl_hexapeptide-3
Mol file:616204-22-9.mol

Synonyms:Ac-EEMQRR-NH2;acetyl hexapeptide-8;acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide;argireline

Suppliers and Price of Argireline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Ac-EEMQRR-NH2 trifluoroacetate salt ≥95% (HPLC)
1mg
$ 318.00

Crysdot
Argireline 98+%
100mg
$ 220.00

Crysdot
Argireline 98+%
10mg
$ 152.00

American Custom Chemicals Corporation
ARGIRELINE 95.00%
10MG
$ 3260.00

American Custom Chemicals Corporation
ARGIRELINE 95.00%
5MG
$ 1830.00

American Custom Chemicals Corporation
ARGIRELINE 95.00%
1MG
$ 686.00

Total 269 raw suppliers

Chemical Property of Argireline

Chemical Property:

Appearance/Colour:white powder
Refractive Index:1.66
PKA:4.43±0.10(Predicted)
PSA：484.48000
Density:1.54 g/cm³
LogP:0.80300
Storage Temp.:?20°C
Solubility.:water soluble
XLogP3:-6.3
Hydrogen Bond Donor Count:14
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:32
Exact Mass:888.42358458
Heavy Atom Count:61
Complexity:1610

Purity/Quality:

97% ^*data from raw suppliers

Ac-EEMQRR-NH2 trifluoroacetate salt ≥95% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCSC)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N
Isomeric SMILES:CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N
Recent ClinicalTrials:Argireline in Treatment of Periorbital Wrinkles
Description Argireline is made up of chains of amino acids. Such chains can affect how our cells work, e.g. relaxing our face muscles. It is derived from the peptide Acetyl hexapeptide-3, a substrate of Botulinum toxin, or more commonly known as Botox.
Uses Argireline is an anti-wrinkle peptide. Synthetically produced and considered to be highly effective, clinical studies indicate it can reduce the depth of existing wrinkles. May be incorporated into products marketed as having a topical-BoToX. or “wrinkle-erasing” effect.

Technology Process of Argireline

There total 2 articles about Argireline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.16%

: C₂₀H₁₈N₂O₁₁S₂^(2-)*2Na⁽¹⁺⁾

: C₂₄H₂₅NO₁₂S₂^(2-)*2Na⁽¹⁺⁾

: C₂₀H₁₉NO₁₀S₃^(2-)*2Na⁽¹⁺⁾

: C₂₁H₂₂N₄O₁₀S₂^(2-)*2Na⁽¹⁺⁾

: 616204-22-9
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂

Guidance literature:: C₂₁H₂₂N₄O₁₀S₂^(2-)*2Na⁽¹⁺⁾; With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime; In water; at 20 ℃; for 0.75h;

With sodium hydroxide; In water; for 0.0833333h;

C₂₀H₁₈N₂O₁₁S₂^(2-)*2Na⁽¹⁺⁾; C₂₄H₂₅NO₁₂S₂^(2-)*2Na⁽¹⁺⁾; C₂₀H₁₉NO₁₀S₃^(2-)*2Na⁽¹⁺⁾; C₂₁H₂₂N₄O₁₀S₂^(2-)*2Na⁽¹⁺⁾; acetyl source; Further stages;
DOI:10.1002/anie.202003676

Reference yield:

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 108-24-7
acetic anhydride

: 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

: 132327-80-1,200623-62-7
Fmoc-L-Gln(Trt)-OH

: 187618-60-6
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 616204-22-9
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂

Guidance literature:: Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

With piperidine; In N,N-dimethyl-formamide; at 25 ℃;

Fmoc-Glu(OtBu)-OH; acetic anhydride; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine; Fmoc-L-Gln(Trt)-OH; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;