N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione

Base Information

Chemical Name:N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione
CAS No.:216581-49-6
Molecular Formula:C₁₇H₁₅NO₄S₂
Molecular Weight:361.442
Hs Code.:

Synonyms:N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione

There total 7 articles about N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 96-53-7
2-mercaptothiazoline

: 216581-47-4
3-(benzyloxy)-6-methyl-4-oxo-4H-pyran-2-carboxylic acid

: 216581-49-6
N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 24h;
DOI:10.1016/S0968-0896(00)00273-X

Reference yield:

: 644-46-2
allomaltol

: 216581-49-6
N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / aq. NaOH / 12 h / 25 °C

2: 80 percent / aq. NaOH / methanol / 12 h / Heating

3: 87.7 percent / Et₃N; SO₃*pyridine / CHCl₃; dimethylsulfoxide / 12 h / 25 °C

4: 85 percent / NaClO₂; NH₂SO₃H / acetone; H₂O / 1 h / 25 °C

5: 71 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 25 °C

With dmap; sodium hydroxide; sodium chlorite; pyridine-SO₃ complex; aminosulfonic acid; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0968-0896(00)00273-X

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 216581-49-6
N-(3-benzyloxy-6-methyl-pyran-4(1H)-one-2-carbonyl)-1,3-thiazolidine-2-thione

Guidance literature:: Multi-step reaction with 7 steps

1: 75.9 percent / SOCl₂ / 1 h / 25 °C

2: 62.8 percent / Zn; conc. HCl / H₂O / 70 - 80 °C

3: 82 percent / aq. NaOH / 12 h / 25 °C

4: 80 percent / aq. NaOH / methanol / 12 h / Heating

5: 87.7 percent / Et₃N; SO₃*pyridine / CHCl₃; dimethylsulfoxide / 12 h / 25 °C

6: 85 percent / NaClO₂; NH₂SO₃H / acetone; H₂O / 1 h / 25 °C

7: 71 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 25 °C

With hydrogenchloride; dmap; sodium hydroxide; sodium chlorite; thionyl chloride; pyridine-SO₃ complex; aminosulfonic acid; triethylamine; dicyclohexyl-carbodiimide; zinc; In methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0968-0896(00)00273-X