96-53-7Relevant academic research and scientific papers
An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water
Liu, Xing,Liu, Min,Xu, Wan,Zeng, Meng-Tian,Zhu, Hui,Chang, Cai-Zhu,Dong, Zhi-Bing
, p. 5591 - 5598 (2017/12/06)
An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols, benzoxazole-2-thiols and benzimidazoline-2-thiones by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.
A convenient synthesis of new annelated pyrimidines and their biological importance
Wahab Khan,Uddin, Mohammed Kabir,Ali, Morshed,Rahman, Mohammad S.,Rashid, Mohammad Abdur,Chowdhury, Rasheduzzaman
, p. E216-E221 (2014/11/07)
Several bicyclic/tricyclic-fused pyrimidines were synthesized from the reactions of amino esters and bifunctional nucleophiles such as 2-methylthio-thiazoline and 2-methylthio-imidazoline. The synthesized compounds were tested for their in vitro antimicrobial activities that revealed mild to moderate growth inhibitory potentials.
Hexadentate terephthalamide(bis-hydroxypyridinone) ligands for uranyl chelation: Structural and thermodynamic consequences of ligand variation (1)
Szigethy, Geza,Raymond, Kenneth N.
supporting information; experimental part, p. 7942 - 7956 (2011/07/06)
Several linear, hexa- and tetradentate ligands incorporating a combination of 2,3-dihydroxy-terephthalamide (TAM) and hydroxypyridinone-amide (HOPO) moieties have been developed as uranyl chelating agents. Crystallographic analysis of several {UO2[TAM(HOPO)2]}2- complexes revealed a variable and crowded coordination geometry about the uranyl center. The TAM moiety dominates the bonding in hexadenate complexes, with linker rigidity dictating the equality of equatorial U-O bonding. Hexadentate TAM(HOPO)2 ligands demonstrated slow binding kinetics with uranyl affinities on average 6 orders of magnitude greater than those of similarly linked bis-HOPO ligands. Study of tetradentate TAM(HOPO) ligands revealed that the high uranyl affinity stems primarily from the presence of the TAM moiety and only marginally from increased ligand denticity. Uranyl affinities of TAM(HOPO)2 ligands were within experimental error, with TAM(o-phen-1,2-HOPO)2 exhibiting the most consistent uranyl affinity at variable pH.
SUGAR CHEMISTRY WITHOUT PROTECTING GROUPS: A NOVEL REGIOSELECTIVE SYNTHESIS OF 6-O-ACYL-D-GLUCOPYRANOSES AND METHYL-6-O-ACYL-α-D-GLUCOPYRANOSIDES
Plusquellec, Daniel,Baczko, Krystyna
, p. 3809 - 3812 (2007/10/02)
The primary hydroxyl groups of α-D-glucose and methyl-α-D-glucoside were selectively esterified by treating the free sugars with N-acylthiazolidine-2-thiones, thus affording respectively 6-O-acyl-D-glucopyranoses and methyl-6-O-acyl-α-D-glucopyranosides in high yields.This new reaction is compared with our previous synthesis of 1-O-acyl-β-D-glucopyranoses from β-D-glucose and interpreted in terms of anomeric effect.
The reduction of specific disulfides with titanium(III) chloride
Akers, Hugh A.,Vang, Meng C.,Updike, Tracie D.
, p. 1364 - 1366 (2007/10/02)
The reaction between titanium(III) chloride and disulfides was investigated.Aryl and alkyl disulfides did not react while heterocyclic aromatic disulfides with a nitrogen α to the sulfur were reduced to the corresponding thiols.Products were identified and characterized by nuclear magnetic resonance and inrared spectra; and melting point comparisons with authentic compounds.The reductions occurred only in the presence of citrate and were found to require 2 moles of titanium(III) per mole of disulfide.
Acylamino-cephem-carboxylic acids containing an amidino or guanidino group in the molecule
-
, (2008/06/13)
Acylamino-cephem-carboxylic acids of the formula I STR1 in which R1, R2 and R3 represent hydrogen or alkyl, R1 and R2 or R2 and R3 together may form an alkylene radical which may be substituted, X represents a single bond or NH, A represents a phenylene or thienylene radical which may be substituted, Y represents a single bond or oxygen and Z represents a 5- or 6-membered ring which may be substituted and which may be bound to an anellated ring system, and their physiologically tolerated salts and esters, a process for preparing these compounds and preparations containing them.
Biologically oriented organic sulfur chemistry. 15. Organic disulfides and related substances. 41. Inhibition of the fungal pathogen Histoplasma capsulatum by some organic disulfides
Field,Grimaldi,Hanley,Holladay,Ravichandran,Schaad,Tate
, p. 996 - 1001 (2007/10/04)
In an extension of promising inhibitory results in vitro against Histoplasma capsulatum, correlated earlier using substituent constants developed by regression analysis with 77 disulfides, one symmetrical and 14 unsymmetrical disulfides were prepared (3-17). About half were active in vitro against H. capsulatum (and one against Candida albicans). Groups that seemed most to lead to promising inhibition among the unsymmetrical disulfides were o-HO2CC6H4, (CH2)SO2Na, Me2NCCS), p-ClC6H4, and perhaps p-CH3C6H4; the first two also might be used to increase solubility. Earlier inhibitory promise of the morpholino group did not materialize. None of the group 3-17 was significantly active in vivo. The unsymmetrical disulfides were prepared by reaction of thiols with sulfenyl chlorides or with acyclic or cyclic thiosulfonates. Two six-membered heterocyclic disulfides (5 and 6) were prepared by a novel cyclization, in which carbon disulfide reacted with an (N-alkylamino)ethyl Bunte salt, followed by ring closure; an explanation is suggested for formation of a thiazoline when the N-alkyl group is absent. One of the disulfides disproportionated with astonishing ease (31; 0.3-1 h at 25°C).
