1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester
• CAS No.: 552299-77-1
• Molecular Formula: C₁₄H₂₅NO₄
• Molecular Weight: 271.357
• Mol file: 552299-77-1.mol

Synonyms:1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester

Chemical Property of 1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester

There total 7 articles about 1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

ethyl acrylate (140-88-5,9003-32-1) + ethyl 2-benzyloxymethyl-5-pyridinecarboxylate hydrochloride → 1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester (552299-77-1) + ethyl 2-benzyloxymethyl-1-[2-(ethoxycarbonyl)ethyl]-5-piperidinecarboxylate (655785-26-5)

Guidance literature:

ethyl 2-benzyloxymethyl-5-pyridinecarboxylate hydrochloride; With hydrogen; platinum(IV) oxide; In methanol; for 1h; under 760 Torr;

ethyl acrylate; at 80 ℃; for 20h;

DOI:10.1021/jm020572p

Reference yield: 13.0%

C16H23NO3 + ethyl acrylate (140-88-5,9003-32-1) → 1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester (552299-77-1) + ethyl 2-benzyloxymethyl-1-[2-(ethoxycarbonyl)ethyl]-5-piperidinecarboxylate (655785-26-5)

Guidance literature:

at 80 ℃; for 20h;

Reference yield:

ethyl 6-(hydroxy-methyl)-pyrid-3-yl-carboxylate (35005-81-3) → 1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester (552299-77-1) + ethyl 2-benzyloxymethyl-1-[2-(ethoxycarbonyl)ethyl]-5-piperidinecarboxylate (655785-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / DMF (N,N-dimethyl-formamide) / 20 °C

2: hydrogenchloride / diethyl ether; ethyl acetate

3: hydrogen / platinum(IV) oxide / methanol / 1 h / 760.05 Torr

4: 20 h / 80 °C

With hydrogenchloride; hydrogen; sodium hydride; platinum(IV) oxide; In methanol; DMF (N,N-dimethyl-formamide); diethyl ether; ethyl acetate;

upstream raw materials:

ethyl acrylate

ethyl 6-(hydroxy-methyl)-pyrid-3-yl-carboxylate

ethyl 2-benzyloxymethyl-5-pyridinecarboxylate

ethyl 2-benzyloxymethyl-5-pyridinecarboxylate N-oxide