Ethyl 2-Benzyloxymethyl-5-pyridinecarboxylate

Base Information

• Chemical Name: Ethyl 2-Benzyloxymethyl-5-pyridinecarboxylate
• CAS No.: 552299-74-8
• Molecular Formula: C16H17NO3
• Molecular Weight: 271.316
• DSSTox Substance ID: DTXSID30451006
• Mol file: 552299-74-8.mol

Synonyms:Ethyl 2-Benzyloxymethyl-5-pyridinecarboxylate;552299-74-8;SCHEMBL6354131;DTXSID30451006;YTZRXBPNCXHOIM-UHFFFAOYSA-N

Chemical Property of Ethyl 2-Benzyloxymethyl-5-pyridinecarboxylate

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 271.12084340
• Heavy Atom Count: 20
• Complexity: 289

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C1=CN=C(C=C1)COCC2=CC=CC=C2

Technology Process of Ethyl 2-Benzyloxymethyl-5-pyridinecarboxylate

There total 1 articles about Ethyl 2-Benzyloxymethyl-5-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

benzyl bromide (100-39-0) + ethyl 6-(hydroxy-methyl)-pyrid-3-yl-carboxylate (35005-81-3) → ethyl 2-benzyloxymethyl-5-pyridinecarboxylate (552299-74-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1021/jm020572p

Reference yield: 84.0%

ethyl 2-benzyloxymethyl-5-pyridinecarboxylate (552299-74-8) → ethyl 2-benzyloxymethyl-5-pyridinecarboxylate N-oxide (552299-79-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 - 20 ℃; for 4h;

DOI:10.1021/jm020572p

Reference yield:

ethyl 2-benzyloxymethyl-5-pyridinecarboxylate (552299-74-8) → ethyl 2-benzyloxymethyl-5-pyridinecarboxylate hydrochloride

Guidance literature:

With hydrogenchloride; In diethyl ether; ethyl acetate;

upstream raw materials:

benzyl bromide

ethyl 6-(hydroxy-methyl)-pyrid-3-yl-carboxylate

Downstream raw materials:

ethyl 2-benzyloxymethyl-5-pyridinecarboxylate N-oxide

ethyl (2RS)-2-benzyloxymethyl-1,2,3,4-tetrahydro-5-pyridinecarboxylate

1-(2-Ethoxycarbonyl-ethyl)-6-methyl-piperidine-3-carboxylic acid ethyl ester

ethyl 2-benzyloxymethyl-1-[2-(ethoxycarbonyl)ethyl]-5-piperidinecarboxylate