2(1H)-Pyridinone, 3-bromo-4-hydroxy-

Base Information

• Chemical Name: 2(1H)-Pyridinone, 3-bromo-4-hydroxy-
• CAS No.: 96245-97-5
• Molecular Formula: C5H4 Br N O2
• Molecular Weight: 189.99500
• Hs Code.: 2933399090
• Mol file: 96245-97-5.mol

Synonyms:2(1H)-Pyridone, 3-bromo-4-hydroxy- (6CI);2,4-Dihydroxy-3-bromopyridine; 3-Bromo-2,4-pyridinediol;3-Bromo-4-hydroxy-2(1H)-pyridinone

Chemical Property of 2(1H)-Pyridinone, 3-bromo-4-hydroxy-

Chemical Property:

• Vapor Pressure: 0.00144mmHg at 25°C
• Melting Point: 263.5-264.5 °C (decomp)
• Boiling Point: 263.5ºC at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 113.2ºC
• PSA: 53.09000
• Density: 2.044g/cm3
• LogP: 0.84300
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromopyridine-2,4-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyridinone, 3-bromo-4-hydroxy-

There total 4 articles about 2(1H)-Pyridinone, 3-bromo-4-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-deazauracil (626-03-9,84719-31-3) → 3-bromo-2,4-dihydroxypyridine (96245-97-5)

Guidance literature:

With hydrogen bromide; bromine; acetic acid; In water; at 0 ℃; for 0.5h;

DOI:10.1002/ejoc.201200721

Reference yield:

4-hydroxy-2-pyridone (626-03-9) → 3-bromo-4-hydroxy-2(1H)-pyridinone (96245-97-5)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 3h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol9023437

Reference yield:

3,5-dibromo-2,4-dihydroxypyridine (80791-78-2) → 3-bromo-2,4-dihydroxypyridine (96245-97-5)

Guidance literature:

With sodium hydroxide; palladium on activated charcoal; Hydrogenation;

upstream raw materials:

3-deazauracil

3,5-dibromo-2,4-dihydroxypyridine

4-hydroxy-2-pyridone

Downstream raw materials:

5-bromo-pyridine-2,4-diol

5-bromo-2,4-dihydroxy-3-nitropyridine

4-amino-2,3-dichloropyridine

2,3-dibromopyridin-4-amine

Refernces

• 1、 Lamblin, Marc,Bares, Hugo,Dessolin, Jean,Marty, Christel,Bourgougnon, Nathalie,Felpin, Francois-Xavier. "Practical Pd/C-catalysed suzuki-miyaura reactions for the preparation of 3-aryl-4-oxypyridin-2(1H)-ones, 3-aryl-2,4-oxypyridines and 3-aryl-2,4- oxyquinolines as useful intermediates for the synthesis of biologically active compounds". . p. 5525 - 5533. Retrieved 2012/10/29.
• 2、 Walters,Carter,Banerjee. "A practical 2,3-pyridyne precursor". . p. 2829 - 2837. Retrieved 2007/10/02.