furo[2,3-c]pyridin-7(6H)-one

Base Information

• Chemical Name: furo[2,3-c]pyridin-7(6H)-one
• CAS No.: 84400-98-6
• Molecular Formula: C7H5NO2
• Molecular Weight: 135.1201
• Hs Code.: 2934999090
• European Community (EC) Number: 959-343-8
• DSSTox Substance ID: DTXSID90510845
• Nikkaji Number: J1.938.338E
• Wikidata: Q82369374
• Mol file: 84400-98-6.mol

Synonyms:furo[2,3-c]pyridin-7(6H)-one;84400-98-6;Furo[2,3-c]pyridine-7(6H)-one;6H-furo[2,3-c]pyridin-7-one;MFCD01544382;6H,7H-FURO[2,3-C]PYRIDIN-7-ONE;SCHEMBL660982;DTXSID90510845;SHSNAKRNZGOTJL-UHFFFAOYSA-N;6-H-furo[2,3-c]pyridin-7-one;AKOS006220930;BS-3582;PB32246;SY244801;CS-0053942;FT-0685644;P10185;A902345;J-521403;F1907-2291

Chemical Property of furo[2,3-c]pyridin-7(6H)-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.558
• Boiling Point: 372.805 °C at 760 mmHg
• Flash Point: 179.266 °C
• PSA: 46.00000
• Density: 1.288 g/cm³
• LogP: 1.12110
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 135.032028402
• Heavy Atom Count: 10
• Complexity: 188

Purity/Quality:

97% ^*data from raw suppliers

Furo[2,3-c]pyridine-7(6H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC(=O)C2=C1C=CO2

Technology Process of furo[2,3-c]pyridin-7(6H)-one

There total 6 articles about furo[2,3-c]pyridin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.8%

3-(furan-3-yl)prop-2-enoylazide (84400-97-5) → furo<2,3-c>pyridin-7(6H)-one (84400-98-6)

Guidance literature:

With tributyl-amine; In various solvent(s); at 175 - 185 ℃;

Reference yield: 64.0%

chloroformic acid ethyl ester (541-41-3) + (E)-3-furan-3-yl-acrylic acid (39244-10-5,81311-95-7) → furo<2,3-c>pyridin-7(6H)-one (84400-98-6)

Guidance literature:

chloroformic acid ethyl ester; (E)-3-furan-3-yl-acrylic acid; With triethylamine; In acetone; at 0 ℃; for 0.666667h;

With sodium azide; In water; acetone; at 0 ℃; for 1h;

With tributyl-amine; In diphenyl Methane; benzene; at 220 ℃; for 1.5h;

Reference yield: 64.0%

3-(furan-3-yl)prop-2-enoic acid (39244-10-5) + chloroformic acid ethyl ester (541-41-3) → furo<2,3-c>pyridin-7(6H)-one (84400-98-6)

Guidance literature:

3-(furan-3-yl)prop-2-enoic acid; chloroformic acid ethyl ester; With triethylamine; In acetone; Cooling with ice;

With sodium azide; In water; acetone; for 1h; Cooling with ice;

With tributyl-amine; diphenylamine; at 220 ℃; for 1.5h;

DOI:10.1248/cpb.57.34

upstream raw materials:

3-(furan-3-yl)prop-2-enoylazide

chloroformic acid ethyl ester

(E)-3-furan-3-yl-acrylic acid

3-(furan-3-yl)prop-2-enoic acid

Downstream raw materials:

7-Chlorofuro[2,3-c]pyridine

2-nitro-N-[2-(7-oxo-7H-furo[2,3-c]pyridin-6-yl)ethyl]-N-[3-(tetrahydropyran-2-yloxy)propyl]benzenesulfonamide

C₁₃H₇F₂NO₂