(S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide

Base Information

• Chemical Name: (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide
• CAS No.: 188974-48-3
• Molecular Formula: C₁₇H₂₀FN₃O₃
• Molecular Weight: 333.363

Synonyms:(S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide

Chemical Property of (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide

Chemical Property:

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Technology Process of (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide

There total 8 articles about (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-N-{3-[3-fluoro-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]-2-oxooxazolidin-5-yl-methyl}acetamide (195816-24-1) → (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide (188974-48-3)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

(S)-(-)-4-[4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]-3,6-dihydro-1(2H)-pyridinecarboxylic acid 1,1-dimethylethyl ester (188975-28-2) → (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide (188974-48-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

Reference yield:

N-((5S)-3-(3-fluoro-4-(1,2,5,6-tetrahydropyrid-4-yl)phenyl)-2-oxooxazolidin-5-ylmethyl)acetamide, hydrochloride salt → (S)-(-)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)-3-fluorophenyl]-5-oxazolidinyl]methyl]acetamide (188974-48-3)

Guidance literature:

With ammonia; In water; ethyl acetate;

upstream raw materials:

(S)-N-{3-[3-fluoro-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]-2-oxooxazolidin-5-yl-methyl}acetamide

(S)-(-)-4-[4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]-3,6-dihydro-1(2H)-pyridinecarboxylic acid 1,1-dimethylethyl ester

(R)-N-{3-[3-fluoro-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]-2-oxooxazolidin-5-yl-methyl}azide

(5R)-3-(4-(1-Benzyl-1,2,5,6-tetrahydropyridin-4-yl)-3-fluorophenyl)-5-hydroxymethyl-oxazolidin-2-one

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