188975-28-2Relevant academic research and scientific papers
Antibiotic oxazolidinone derivatives
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Referential example 2, (2010/01/31)
The invention concerns a compound of the formula (I): wherein, for example: R1is of the formula —NHC(═O)Rbwherein Rbis, for example, (1-4C)alkyl; R2and R3are hydrogen or fluoro; R2and R3are hydrogen or fluoro; D is O; R4and R5are hydrogen, (1-4C)alkyl or AR-oxymethyl; AR is phenyl or phenyl(1-4C)alkyl; R6is hydrogen; >A—B— is of the formula >C═C(Ra)—, >CHCHRa—, or >C(OH)CHRa— (> represents two single bonds) wherein Rais hydrogen or (1-4C)alkyl; and pharmaceutically-acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.
Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
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, (2008/06/13)
A compound of the formula (I): STR1 or pharmaceutical acceptable salts thereof wherein X is NR1, S(O)g, or O; R1 is H, C1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R1 is --(CH2)h -- aryl, --COR1--1, --COOR1-2, --CO--(CH2)h --COR1--1, C1-6 alkyl sulfonyl, --SO2 --(CH2)h --aryl, or --(CO)i --Het; R2 is H, C1-6 alkyl, --(CH2)h --aryl, or halo; R3 and R4 are the same or different and are H or halo; R5 is H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.
Antibiotic oxazolidinone derivatives
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, (2008/06/13)
The invention concerns a compound of formula (I): STR1 wherein R1 -R6, A, B, and D have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising
