1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone

Base Information

• Chemical Name: 1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone
• CAS No.: 123547-33-1
• Molecular Formula: C₂₂H₂₉N₅O₃
• Molecular Weight: 411.504

Synonyms:1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone

Chemical Property of 1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone

Chemical Property:

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Technology Process of 1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone

There total 6 articles about 1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(3-nitrophenyl)piperazine (54054-85-2) + 1-(1-methylpyrrol-2-ylmethyl)-2-piperidinone (123547-52-4) → 1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone (123547-33-1)

Guidance literature:

With acetic acid; Yield given. Multistep reaction; 1.) MeOH, H₂O, 25 deg C, 5 min, 2.) MeOH, H₂O, 25 deg C, overnight;

DOI:10.1021/jm00081a018

Reference yield:

N-methylpyrrole aldehyde (1192-58-1) → 1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone (123547-33-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 5A molecular sieves, Et₃N / CHCl₃ / 4 h / 25 °C

2: H₂ / PtO₂ / methanol / 35 - 39 Torr

3: 72 percent / toluene / 8 h / Heating

4: 1.) AcOH / 1.) MeOH, H₂O, 25 deg C, 5 min, 2.) MeOH, H₂O, 25 deg C, overnight

With 5A molecular sieve; hydrogen; acetic acid; triethylamine; platinum(IV) oxide; In methanol; chloroform; toluene;

DOI:10.1021/jm00081a018

Reference yield:

methyl 5-aminovalerate (63984-02-1) → 1-[[1-methyl-5-[[4-(3-nitrophenyl)-1-piperazinyl]-methyl]-1H-pyrrol-2-yl]-methyl]-2-piperidinone (123547-33-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 5A molecular sieves, Et₃N / CHCl₃ / 4 h / 25 °C

2: H₂ / PtO₂ / methanol / 35 - 39 Torr

3: 72 percent / toluene / 8 h / Heating

4: 1.) AcOH / 1.) MeOH, H₂O, 25 deg C, 5 min, 2.) MeOH, H₂O, 25 deg C, overnight

With 5A molecular sieve; hydrogen; acetic acid; triethylamine; platinum(IV) oxide; In methanol; chloroform; toluene;

DOI:10.1021/jm00081a018

upstream raw materials:

formaldehyd

1-(3-nitrophenyl)piperazine

1-(1-methylpyrrol-2-ylmethyl)-2-piperidinone

N-methylpyrrole aldehyde

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