N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester

Base Information

• Chemical Name: N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester
• CAS No.: 1643359-99-2
• Molecular Formula: C₂₃H₂₂F₃N₃O₃
• Molecular Weight: 445.441
• Mol file: 1643359-99-2.mol

Synonyms:N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester

Chemical Property of N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester

There total 10 articles about N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-Iodobenzotrifluoride (455-13-0) + N-α-acetyl-1-benzyl-L-histidine methyl ester → N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester (1643359-99-2)

Guidance literature:

With copper(l) iodide; potassium tert-butylate; palladium diacetate; catacxium A; Trimethylacetic acid; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 0.75h; Reagent/catalyst; Solvent; regioselective reaction; Catalytic behavior; Inert atmosphere; Microwave irradiation; Sealed tube;

DOI:10.1039/c4ob00430b

Reference yield: 48.0%

p-trifluoromethylphenyl bromide (402-43-7) + N-α-acetyl-1-benzyl-L-histidine methyl ester → N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester (1643359-99-2)

Guidance literature:

With copper(l) iodide; potassium tert-butylate; palladium diacetate; catacxium A; Trimethylacetic acid; In 1-methyl-pyrrolidin-2-one; at 140 ℃; regioselective reaction; Inert atmosphere; Microwave irradiation; Sealed tube;

DOI:10.1039/c4ob00430b

Reference yield: 38.0%

4-Iodobenzotrifluoride (455-13-0) + N-α-acetyl-1-benzyl-L-histidine methyl ester → N-α-acetyl-5-(4-trifluoromethylphenyl)-1-benzyl-L-histidinemethyl ester + N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester (1643359-99-2) + C30H25F6N3O3 (1643360-29-5)

Guidance literature:

With copper(l) iodide; tricyclohexylmethane; palladium diacetate; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 140 ℃; for 0.75h; Reagent/catalyst; regioselective reaction; Catalytic behavior; Inert atmosphere; Microwave irradiation;

DOI:10.1039/c4ob00430b

upstream raw materials:

p-trifluoromethylphenyl bromide

4-Iodobenzotrifluoride

N^α-acetyl-L-histidine methyl ester

benzyl bromide

Downstream raw materials:

N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester