N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester

Base Information

• Chemical Name: N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester
• CAS No.: 1643360-00-2
• Molecular Formula: C₁₆H₁₆F₃N₃O₃
• Molecular Weight: 355.317
• Mol file: 1643360-00-2.mol

Synonyms:N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester

Chemical Property of N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester

There total 5 articles about N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester (1643359-99-2) → N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester (1643360-00-2)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; for 18h; Reflux;

DOI:10.1039/c4ob00430b

Reference yield:

N-α-acetyl-1-benzyl-L-histidine methyl ester → N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester (1643360-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: catacxium A; copper(l) iodide; Trimethylacetic acid; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.75 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2: palladium 10% on activated carbon; ammonium formate / methanol / 18 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; ammonium formate; potassium carbonate; catacxium A; Trimethylacetic acid; In methanol; N,N-dimethyl-formamide;

DOI:10.1039/c4ob00430b

Reference yield:

Nα-acetyl-L-histidine methyl ester (36097-48-0) → N-α-acetyl-2-(4-trifluoromethylphenyl)-L-histidine methyl ester (1643360-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: silver carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2: catacxium A; potassium tert-butylate; palladium diacetate; copper(l) iodide; Trimethylacetic acid / 1-methyl-pyrrolidin-2-one / 0.75 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: palladium 10% on activated carbon; ammonium formate / methanol / 18 h / Reflux

With copper(l) iodide; palladium 10% on activated carbon; potassium tert-butylate; ammonium formate; palladium diacetate; silver carbonate; catacxium A; Trimethylacetic acid; In 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;

DOI:10.1039/c4ob00430b

upstream raw materials:

p-trifluoromethylphenyl bromide

N-α-acetyl-2-(4-trifluoromethylphenyl)-1-benzyl-L-histidine methyl ester

N^α-acetyl-L-histidine methyl ester

4-Iodobenzotrifluoride