(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt

Base Information

Chemical Name:(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt
CAS No.:1173157-59-9
Molecular Formula:C₂HF₃O₂*C₂₃H₃₁N₃O₄
Molecular Weight:527.541
Hs Code.:

Synonyms:(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt

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Chemical Property of (2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt

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Technology Process of (2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt

There total 8 articles about (2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173157-62-4
C₂₇H₃₅N₃O₆

: 76-05-1
trifluoroacetic acid

: 1173157-59-9
(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt

Guidance literature:: C₂₇H₃₅N₃O₆; With diethylamine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In water; acetonitrile; at 22 ℃; for 0.5h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 100564-78-1,108524-68-1,142926-43-0,82732-07-8
(2R)-(tert-butoxycarbonylamino)-4-phenylbutanoic acid

: 1173157-59-9
(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / dichloromethane; diethyl ether / 0.5 h / 22 °C

2: hydroxylamine hydrochloride; potassium hydroxide / methanol / 4.25 h / 0 - 22 °C

3: potassium carbonate / N,N-dimethyl-formamide / 13 h / 0 - 22 °C

4: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 0.5 h / 22 °C

With methanol; hydroxylamine hydrochloride; potassium carbonate; diethylamine; potassium hydroxide; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1173157-59-9
(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.25 h

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.58 h / 0 - 22 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 13 h / 0 - 22 °C

5.1: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 0.5 h / 22 °C

With lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; diethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;